Cisplatin aki

Author: mjde

August undefined, 2024

WebIn a preclinical mouse model, intraperitoneal perfusion with cisplatin induced AKI, whereas hyperthermia alone, or in combination with cisplatin, did not induce or enhance renal injury. Amifostine failed to confer nephroprotective effects in a miniaturized HIPEC model. Conclusions: AKI is a frequent complication after HIPEC. The risk of renal ... WebAims: This study investigated the regulatory effect of Mitofusin2 (Mfn2) on mitochondria-associated endoplasmic reticulum membrane (MAMs) integrity and cellular injury in cisplatin-induced acute kidney injury (CP-AKI). Results: CP- AKI mice exhibited decreased expression of Mfn2, increased expression of phosphorylated adenosine …

Frontiers Kidney-Targeted Redox Scavenger Therapy Prevents …

WebMar 29, 2024 · Administration of the chemotherapeutic agent cisplatin leads to acute kidney injury (AKI). Cisplatin-induced AKI (CIAKI) has a complex pathophysiological map, which … WebOct 1, 2024 · Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney injury (AKI). Patients who develop AKI have an increased risk of mortality and are more likely to develop chronic kidney disease (CKD). flys cheaps

Rapamycin Perfluorocarbon Nanoparticle Mitigates Cisplatin …

WebOct 1, 2024 · Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney injury (AKI). Patients who develop AKI have an increased risk of mortality and are more likely to develop chronic kidney disease (CKD). WebPurpose: Cisplatin-induced acute kidney injury (CIA) is a serious adverse event that affects 20-40% of exposed patients, despite any implemented precaution to avoid it. The aim of this work was therefore to identify a relevant nephroprotective method for CIA. Methods: We searched Pubmed, Embase, and Web of Science from 1 January 1978 to 1 June … WebAug 12, 2024 · In AKI, studies have shown that IL-10 can protect against ischemia, cisplatin, or ureteric obstruction–induced renal injury by limiting inflammatory cytokine production and immune cell infiltration ( 4, 5 ), indicating that IL-10 may be a potential therapy to tackle the current clinical challenges of AKI treatment. flyschoidi

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Developing better mouse models to study cisplatin-induced …

WebIn this study, mRNA sequencing was performed by intraperitoneal injection of cisplatin to induce AKI model to detect differentially expressed genes. All SD rats (male, 6 weeks, n = 6) were purchased from Shanghai Slac Laboratory Animal Co. Ltd and housed in the Experimental Animal Center of Tongji University. Rats were raised in a 2-hour dark ... WebDiscussion. In a previous study, we showed that DM was the high-risk factor for cisplatin-induced AKI. 5 However, no attempt was made to identify the mechanism for the … greenpeace rallyWebOct 13, 2024 · Cisplatin-induced acute kidney injury (AKI), characterized by rapid loss of renal function within days of initiating treatment, occurs in around 30% of patients who … greenpeace rainbow warriors cd

"WebSep 2, 2024 · Acute kidney injury (AKI) is a common complication that accounts for death in patients with sepsis, and the incidence of AKI is increasing year by year. The morbidity of AKI in community hospitals is as low as 2%, whereas in large medical institutions, rates can be more than 20% of all hospitalizations ( Bellomo et al., 2012 ). " - Cisplatin aki

Cisplatin aki

WebA known complication of cisplatin administration is acute kidney injury (AKI). The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates … WebCisplatin for injection has been administered at 75 mg/m. 2 . to 100 mg/m. intravenously per cycle once every 3 to 4 weeks on Day 1. Other doses and combination regimens have …

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WebOct 13, 2024 · A single dose of 10 mg/kg cisplatin was reported to induce substantial upregulation of mitochondrial electron transport chain complex I activity and mitochondrial superoxide in mouse kidneys 6... WebMar 15, 2016 · Cisplatin, a chemotherapeutic used for the treatment of solid cancers, has nephrotoxic side effects leading to acute kidney injury (AKI). Cisplatin cannot be given to patients that have comorbidities that predispose them to an increased risk for AKI. Even without these comorbidities, 30% of patients administered cisplatin will develop kidney ...

Web42%–100% of patients depending on total cisplatin dose and length of exposure. Hypomagnesemia and renal magnesium wasting may persist for up to 6 years after initial dose (5). Renal salt wasting syndrome has been reported in up to 10% of patients, manifesting as hyponatremia and severe ortho-static hypotension in the setting of high … WebFeb 1, 2016 · Cisplatin, a commonly used cancer chemotherapeutic, has a dose-limiting side effect of nephrotoxicity. Approximately 30% of patients administered cisplatin suffer from kidney injury, and there are limited treatment options for the treatment of cisplatin-induced kidney injury.

WebBackground: Acute kidney injury (AKI) is a common kidney disease with a high risk of death and can develop into chronic kidney disease (CKD) and renal failure eventually. Curcumin, an herbal supplement, has been reported exhibiting a renoprotective role in AKI. However, the underlying mechanism is largely unclear. WebMay 8, 2024 · Serum Creatinine (SCr)-Acute Kidney Injury (AKI) Staging Outlined by the Kidney Disease: Improving Global Outcomes (KDIGO) Guidelines and Electrolyte-AKI (eAKI) Grading Based on National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) Version 4 eTable 2.

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WebDiscussion. In a previous study, we showed that DM was the high-risk factor for cisplatin-induced AKI. 5 However, no attempt was made to identify the mechanism for the development of AKI in patients with DM. MATE1/SLC47A1, an organic cation transporter in proximal tubular epithelial cells, mediates the tubular secretion of cationic drugs or … greenpeace rainbow warrior shipWebCisplatin is a clinically advanced and highly effective anticancer drug that is used for the treatment of various solid tumors, such as lung cancer, stomach cancer, and ovarian … flyschoideWebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different … greenpeace rainbow warriors albumWebFeb 16, 2024 · Moreover, kidney function can remain decreased >5 years after cisplatin treatment, regardless of whether the patient had a clinical AKI event 115. Cisplatin AKI is often studied in rodents after a ... flyschool cuatro vientosWebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … flysch rossoWebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), … greenpeace rainforestWebCisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms … flysch permeability value