Cisplatin lysosomes

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August undefined, 2024

WebNov 7, 2024 · Although cisplatin is one of the most common antineoplastic drug, its successful utilisation in cancer treatment is limited by the drug resistance. Multiple … WebMar 1, 2024 · Cisplatin (CDDP) is a widely used agent in the treatment of neuroblastoma. Unfortunately, the development of acquired chemoresistance limits its clinical use. To gain a detailed understanding of the mechanisms underlying the development of such chemoresistance, we comparatively analyzed established …

Autophagy modulating agents as chemosensitizers for cisplatin …

WebLysosomes have been proposed to sequester drugs, including cisplatin, and may therefore contribute to drug resistance. However, the mechanism(s) that facilitate this remains unclear. Our work demonstrates that the CACC TMEM16A drives lysosomal … We would like to show you a description here but the site won’t allow us. WebConfocal microscopy studies for 2a-Cl suggest that complexes localize preferentially in the lysosomes and to a lesser extent on the cytoplasm, but ultimately causing damage to the mitochondria. Finally, the potential photodynamic behaviour of scarcely toxic complexes 2b-Cl, 2b-PF6, 2c-Cl and 3a-PF6 was also studied how many hours is a 0.6 fte

Cisplatin remodels the tumor immune microenvironment …

WebJun 2, 2016 · Cisplatin is a widely prescribed anticancer drug, which triggers cell death by covalent binding to a broad range of biological molecules. Among cisplatin targets, … WebLysosome Fe 2+ release is responsible for etoposide- and cisplatin-induced stemness of small cell lung cancer cells Iron metabolism has been shown to hand over cancer stem cell, which is regarded as the root of tumor progression, recurrence and chemoresistance. how many hours is 9 weeks

Proteomic Signature of Neuroblastoma Cells UKF-NB-4 Reveals …

Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome …

WebOct 13, 2024 · Cisplatin is an inorganic platinum derivative that is widely used for chemotherapy of various solid tumours. In cancer cells, cisplatin induces DNA crosslinks and DNA adducts, triggering the... WebJan 28, 2014 · We conclude that TRIM38 negatively regulates TNFα- and IL-1β-induced signaling by mediating lysosome-dependent degradation of TAB2/3, two critical components in TNFα- and IL-1β-induced signaling pathways. Our findings reveal a previously undiscovered mechanism by which cells keep the inflammatory response in … how a nerve impulse is transmittedWebMay 10, 2024 · This HIF/Ferritin axis is responsible for etoposide- and cisplatin-induced iron reduction in lysosomes and stemness of SCLC cells. This work demonstrates that … how a nerve impulse is generated

"WebCisplatin, a class of platinum-containing anticancer drugs for the treatment of solid tumors, is a substrate of OCT2 and MATE1/MATE2-K. OCT2 is expressed in the basolateral … " - Cisplatin lysosomes

Cisplatin lysosomes

Cisplatin nephrotoxicity: new insights and therapeutic implications ...

WebSep 21, 2015 · Platinum-based cisplatin is a first-line therapeutic agent used in the treatment of multiple cancers, including ovarian cancer. Cisplatin acts by inducing DNA damage, triggering cell cycle arrest, and initiating apoptosis ( 4 ). However, many ovarian cancer patients develop acquired cisplatin resistance, resulting in failure of … WebCytoplasmic material is transported to lysosomes for degradation and recovery through autophagy. ... Y. et al. Cisplatin-induced autophagy protects breast cancer cells from apoptosis by regulating ...

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WebAug 3, 2024 · The eukaryotic endomembrane system (EMS) is a set of interrelated membrane-bound organelles that include the endoplasmic reticulum (ER), Golgi, lysosome and the plasma membrane, as well as the vesicles trafficking between them. It is responsible for numerous cellular processes, such as endocytosis and exocytosis. WebNov 2, 2024 · Lysosomal exocytosis is a Ca 2+ -dependent process whereby lysosomes fuse with the plasma membrane and release their contents to the extracellular space [ 74]. Interestingly, lysosomal …

WebOct 1, 2024 · The Lysosomal pH shift induces nanofibril formation and lysosomal membrane permeation, thereby releasing the lysosomal contents into the cytoplasm and inducing LMP mediated cell death and cisplatin sensitization. Figure … WebLysosomes are specialized organelles for protein recycling and as such are involved in the terminal steps of autophagy. However, it has become evident that lysosomes also play an important role in the progression of apoptosis.

WebApr 22, 2003 · We isolated human KB adenocarcinoma cisplatin-resistant (CP-r) cell lines with multidrug-resistance phenotypes because of reduced accumulation of cisplatin and other cytotoxic compounds such as methotrexate and heavy metals. WebThe nanomaterial consists of peptide amphiphiles, which self-assemble into nanoparticles, colocalize with the lysosome, and change conformation to nanofibrils due to lysosomal pH shift, which leads to the disruption of the lysosome, cell death, and cisplatin sensitization.

WebOct 1, 2024 · Cisplatin, sequestered in the lysosome is freed by the LMP action of CPTNPs, allowing for increased availability of cisplatin and increased cell death. (For …

WebJun 5, 2024 · Disrupting lysosomes with bafilomycin A1 increased the sensitivity of resistant cells to CDDP (Fig. 2K ). Fig. 2: Therapy-activated TFEB acts as a critical regulator to … how a nerve impulse travels across a synapseWebApr 15, 2003 · Cisplatin (CP) is a component of standard treatment regimens for testicular, ovarian, bladder, cervical, head and neck and small-cell and nonsmall-cell lung cancers (Ozols and Williams, 1989 ... how a nerve impulse is passed along a neuronWebJun 5, 2024 · Disrupting lysosomes with bafilomycin A1 increased the sensitivity of resistant cells to CDDP (Fig. 2K ). Fig. 2: Therapy-activated TFEB acts as a critical regulator to control lysosomal... how an essay should lookWebFeb 1, 2014 · Here we show that a synergistic interaction can be achieved between sunitinib and cisplatin through a mechanism involving both the apoptotic and the autophagic/lysosomal systems. Such drug cooperation results in enhanced growth inhibition and cell death in both MTC cell culture and tumor xenografts. Materials and Methods … how many hours is a 120 minutesWebWestern blotting showed that cisplatin decreased protein expression of E6 and increased protein expression of p53, p21 and Bax. It had no effect on protein expression of Bcl-2. It is concluded that cisplatin can induce apoptosis in HeLa cells by suppressing HPV E6 and thereby restoring the function of p53. Publication types how an esc worksWebNCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine. how an essay is writtenWebSep 25, 2024 · We investigated whether triggering lysosomal membrane permeabilization (LMP) or suppressing autophagy can restore cisplatin susceptibility in lung cancer with … how an essay title should look