Crystallographic refinement of ricin to 2.5 a
WebApr 20, 1986 · The 3-fold redundancy of the asymmetric unit of the crystal cell was used in the refinement process, which proceeded by cyclic averaging, model building and … WebApr 24, 2014 · Crystallographic refinement of ricin to 2.5 Angstroms Submitted by: 3Dprint@NIH Thu, 2014-04-24 21:28 I Printed This Remix It General Information Model Details Attribution This Model was autogenerated from the "Quick Submit" tool. Model ID 3DPX-000021 Category Proteins, Macromolecules and Viruses Keyword (s) …
Crystallographic refinement of ricin to 2.5 a
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WebMar 2, 2024 · Ricin A has three main regions: domain I consist of β -sheets, while domain II is an α -helical structure. Domain III plays a major role in dimer formation by binding to chain B. The active site of ricin contains highly conserved residues (Tyr80, Tyr123, Glu177, Trp211, and Arg180 ( Eswar et al., 2006 ); see Figure 3I ). WebA procedure has been developed for the refinement of crystallographic protein structures based on the biomolecular simulation program Amber.The procedure constructs a model representing a crystal unit cell, which generally contains multiple protein molecules and is fully hydrated with TIP3P water. Periodic boundary conditions are applied to the cell in …
WebA representation of the ricin protein based on X-ray crystallographic data is presented in Figure 27.4. Figure 27.4. Representation of the ricin protein derived from X-ray crystallographic data. The A-chain and B-chain are blue and orange, respectively. Random coil regions are strings, β-sheets are flat ribbons, and α-helices are coiled ribbons. WebCrystallographic refinement by simulated annealing with molecular dynamics has been applied to a 2.8 A (1 A = 0.1 nm) resolution X-ray structure of aspartate aminotransferase, achieving structural changes and improvements of the electron density maps that were not possible by using restrained least-squares refinement without manual re-fitting. …
WebApr 12, 2024 · When Sc content is increased beyond the eutectic point, grain size decreases more significantly. An addition of 0.7 wt.% Sc can refine the grain to 40 μm. Figure 3 b shows that the grain size is fine and uniform, and the reduction rate reaches 95.3%. This difference in refinement results from refinement mechanism. WebApr 7, 2024 · This biomimetic microstructure with a specific crystallographic texture not only enhances tensile strength but also facilitates the oriented adhesion and migration of bone cells. In particular, the fiber texture exposes the low-indexed Ti(0002) crystalline plane to air, allowing the formation of hydrophilic TiO 2 film with crystallographic anatase.
WebJun 4, 2024 · Proteins, Macromolecules and Viruses. STL/VRML Files . 2aai-ribbon-secondary.wrl
WebThe plant cytotoxin ricin consists of two disulfide-linked chains, each of about 30,000 daltons. An initial model based on a 2.8 Å MIR electron density map has been refined … collin berganderWebMar 1, 2004 · The isoelectric point of ricin E, estimated to be 8.8 by ampholine electrophoresis, was higher than that of ricin D. Ricin E had equal toxicity for mice and equal cytoagglutinating activity for ... collin bevier avison youngWebThe plant cytotoxin ricin consists of two disulfide‐linked chains, each of about 30,000 daltons. An initial model based on a 2.8 Å MIR electron density map has been refined against 2.5 Å data using r... collin beck solomon islandsWebApr 7, 2024 · B-cell lymphoma 6 (BCL6) is a transcriptional repressor and oncogenic driver of diffuse large B-cell lymphoma (DLBCL). Here, we report the optimization of our previously reported tricyclic quinolinone series for the inhibition of BCL6. We sought to improve the cellular potency and in vivo exposure of the non-degrading isomer, CCT373567, of our … collin beauty productsWebSep 7, 1993 · Crystallographic refinement of ricin to 2.5 A. Rutenber, E., Katzin, B.J., Ernst, S., Collins, E.J., Mlsna, D., Ready, M.P., Robertus, J.D. (1991) Proteins 10: 240-250. PubMed: 1881880 Search on PubMed; … dr ritceyWebOct 27, 2009 · Crystallographic techniques and methods of structure determination have progressed rapidly in recent years, accompanied by an explosion in the amount of structural information about biological molecules and macromolecular assemblies. dr ritcey sydney nsWebThe plant cytotoxin ricin consists of two disulfide‐linked chains, each of about 30,000 daltons. An initial model based on a 2.8 Å MIR electron density map has been refined … dr ritcher ct