WebSep 22, 2024 · Loss of Nf1 in SCs occurs in the Dhh model at E12.5, yet few SC genes showed altered expression in 2-month-old Dhh-Cre;Nf1 fl/fl cells (Supplemental Table 4). To define Nf1-driven changes, we compared each SC cluster in 7-month PN SCs to controls. Subclustering revealed changes in each SC population that were unique to PNs (Figure … 012929 FVB(Cg)-Tg(Dhh-cre)1Mejr/J The Dhh-cre transgene harbors a nuclear-localized Cre recombinase gene under control of the mouse desert hedgehog ( Dhh ) promoter/regulatory regions. These transgenic mice may be useful in generating cre -inducible mutations in Sertoli cell precursors (testes development/male germline), endothelial cells, and Schwann cells of the peripheral nervous system.
JCI Insight - Cxcr3-expressing leukocytes are necessary for ...
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Gene knockouts that affect Sertoli cell function - ScienceDirect
WebFeb 7, 2024 · Dhh-Cre Nf1 fl/fl survival mice were predominantly sacrificed due to neurofibroma-associated morbidity (e.g., paralysis), while sacrifice of Dhh-Cre Nf1 fl/fl Cxcr3-null mice was typically necessitated by dermatitis (n = 3 mice) and abdominal bloating/lethargy associated with malignancies typical of aged C57/Bl6 mice (n = 5 colon … Web007915 129S.FVB-Tg(Amh-cre)8815Reb/J These Amh-cre transgenic mice have expression of Cre recombinase directed by the testis Sertoli cell-specific promoter elements of the anti-Mullerian hormone ( Amh ) gene. These Amh-cre transgenic mice may be useful in generating conditional knockouts in testis Sertoli cells for studying male embryonic … WebApr 4, 2024 · BIG1 knockout mice (BIG1 fl/fl; Dhh-Cre) showed a decrease in the relative amounts of MPZ in inner myelin sheaths (Fig. 5, A and B). Similar results are obtained from Arf1 knockout mice (Arf1 fl/fl; Dhh-Cre; Fig. 5, C and D), suggesting that BIG1 and Arf1 constitute one of the transporting systems of the myelin component. It is likely that BIG1 ... hiditec inox