The pregnane x receptor
Webb1 juli 2005 · THE PREGNANE X RECEPTOR (PXR; NR1I2), a member of the nuclear hormone receptor (NR) superfamily, is a key regulator of bile salt, steroid hormone, and xenobiotic … Webb1 apr. 2024 · It is well-known that the pregnane X receptor (PXR)/Nr1i2 is a critical xenobiotic-sensing nuclear receptor enriched in liver and intestine and is responsible for …
The pregnane x receptor
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Webb29 sep. 2014 · Pregnane X receptor (PXR) is an important member of the nuclear receptor superfamily that copes with various endobiotic and xenobiotic stimuli, such as carcinogens by regulating an array of environmental response genes. Low PXR expression has been shown to promote tumor initiation and metastasis. The aim of the current study was to … Webb18 apr. 2016 · The nuclear xenobiotic pregnane X receptor (PXR) is well established as a transcriptional regulator of phase I and phase II drug-metabolizing enzymes and drug …
WebbThe pregnane X receptor (PXR) is a member of the nuclear receptor family of ligand-regulated transcription factors. Like many former orphan nuclear receptors, it contains … Webb10 sep. 2024 · Pregnane X Receptor (PXR) is a ligand-activated transcription factor which binds many structurally different molecules. The receptor is able to regulate the …
WebbThe pregnane X receptor (PXR) is a xenobiotic nuclear receptor that is also sensitive to bile acids as ligands.10,11 A study in this issue of Arteriosclerosis, Thrombosis, and … Webb2006 Orphan nuclear receptor pregnane X receptor sen-sitizes oxidative stress responses in transgenic mice and cancerous cells. Mol Endocrinol 20:279–290 24. Curnow KM, Tusie-Luna MT, Pascoe L, Natarajan R, Gu JL, Nadler JL, White PC 1991 The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex. Mol …
WebbEl receptor X de pregnano (PXR), también conocido como NR1I2 (de sus siglas en inglés "nuclear receptor subfamily 1, group I, ... MeSH: pregnane+X+receptor (en inglés) Datos: …
Webb1 juli 2024 · The pregnane X receptor (PXR) is a ligand-activated nuclear receptor that acts as a xenobiotic sensor, responding to compounds of foreign origin, including … greenhouse effect and global warming for kidsWebbFarnesoid X receptor (FXR), a member of the nuclear receptor superfamily that is mainly expressed in enterohepatic tissues, has been discovered as a crucial regulator for balancing liver inflammatory processes and metabolism [ 5, 6, 7] and thus has become a pharmacological target for liver disorders. greenhouse effect and global warming upscWebbPregnane X receptor is a ligand-activated nuclear receptor (NR) that mainly controls inducible expression of xenobiotics handling genes including biotransformation … fly away shuttle laxWebbThe pregnane X-receptor (PXR) and the constitutive androstane receptor (CAR) are orphan nuclear receptors activated by a variety of ligands ( Kretschmer and Baldwin, 2005 ). … fly away shuttle busWebbThe pregnane X receptor (PXR) is a xenobiotic nuclear receptor that is also sensitive to bile acids as ligands.10,11 A study in this issue of Arteriosclerosis, Thrombosis, and Vascular Biology has examined the potential for PXR to regulate hepatic apoA-I and HDL formation in response to bileacids.12 Wild-typemice,miceinwhichthePXRgenehad greenhouse effect and the water cycleWebbPXR is remarkably divergent between species, with the rabbit, rat, and human receptors sharing only approximately 80% amino acid identity in their ligand-binding domains. … fly away significadoWebbWe studied in mice and human adenocarcinoma-derived Caco-2 cells the impact of low calcium on markers of inflammation (cyclooxygenase-2; COX-2), of detoxification (pregnane and xenobiotic receptor (PXR)/steroid and xenobiotic receptor (SXR), … fly away shuttle lax to van nuys